Obesity plays a central role in the insulin resistance syndrome, which is associated with hyperinsulinemia, hypertension, hyperlipidemia, type 2 diabetes mellitus, and an increased risk of atherosclerotic cardiovascular disease. The present study was done to assess the effect of Gymnema sylvestre extract (GSE) in the high fat diet (HFD)-induced cellular obesity and cardiac damage in Wistar rats.

After 4 weeks of treatment, BMI, weight gain, food intake, and all hemodynamic parameters (systolic, diastolic, mean arterial BP and heart rate), were significantly (P < 0.01) increased in HFD treated group (i.e., group II) as compared with the normal control group (i.e., group I). 

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